Webinar 2: Truncation of a-synculein in the appendix & treatment of GBA-associated Parkinson’s

In this session, Bryan Killinger discusses their use of the top-down mass spectrometry approach to identify and quantify alpha-synuclein proteoforms in the vermiform appendix and substantia nigra of patients diagnosed with common synucleinopathies (i.e. Parkinson’s disease, dementia with Lewy bodies). In the second talk, Konstantin Senkevich discusses the pathogenesis and possible approaches for the treatment of GBA-associated PD. Mutations in GBA, which encodes the enzyme glucocerebrosidase (GCase), are the most common genetic risk factors associated with Parkinson’s disease (PD) with a frequency of up to 5-20% among patients.

This webinar series is brought to you by The Cure Parkinson's Trust, the World Parkinson Coalition and Van Andel Institute.

Webinar 2_070420.